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师资概况
缪小平

来源: 时间:2021-09-27 点击量:


  • 职务:教授、博导,中组部首批“青年拔尖人才,教育部新世纪人才

  • 院系:流行病与卫生统计学系

  • 地址:湖北省武汉市航空路13号 430030

  • 电话:

  • 邮箱:miaoxp@hust.edu.cn


缪小平,流行病学教授,担任中国抗癌协会病因专委会副主任委员、中国医师协会公共卫生医师分会总干事和中华医学会公共卫生分会委员。获中国肿瘤青年科学家奖和湖北省自然科学二等奖(排名第一)。曾主持国家自然科学基金优秀青年基金、中组部青年拔尖人才支持计划等人才项目。主要从事肿瘤分子流行病学研究:发现了中国人群结直肠癌、食管癌和胰腺癌的高作用效能易感基因,为个体化预防提供了重要线索,结果分别发表在Cancer ResNat GenetNat Commun;阐明了结直肠癌非编码区易感位点的生物学机制,为充分认识人类基因组“荒漠区”提供了人群证据;揭示了影响结直肠癌易感性的基因-环境和基因-基因交互作用,为构建肿瘤风险预测模型提供了依据。近5年作为通讯作者发表SCI论文31篇,其中IF>108篇,另有6篇入选ESI高被引论文,在web of science数据库中的H指数为46



代表性论文

(详见ResearchID: http://www.researcherid.com/rid/C-4336-2011;

Google scholar: http://scholar.google.co.uk/citations?user=biJN_2kAAAAJ&hl=en )


1. Tian J, Wang Z, Mei S, Yang N, Yang Y, Ke J, Zhu Y, Gong Y, Zou D, Peng X, Wang X, Wan H, Zhong R, Chang J, Gong J, Han L, Miao X. CancerSplicingQTL: a database for genome-wide identification of splicing QTLs in human cancer. Nucleic Acids Res. 2019;47(D1):D909-D916.

2. Yang Y, Peng X, Ying P, Tian J, Li J, Ke J, Zhu Y, Gong Y, Zou D, Yang N, Wang X, Mei S, Zhong R, Gong J, Chang J, Miao X. AWESOME: a database of SNPs that affect protein post-translational modification. Nucleic Acids Res. 2019;47(D1):D874-D880.

3. Chang J, Zhong R, Tian J, Li J, Zhai K, Ke J, Lou J, Chen W, Zhu B, Shen N, Zhang Y, Zhu Y, Gong Y, Yang Y, Zou D, Peng X, Zhang Z, Zhang X, Huang K, Wu T, Wu C*, Miao X*, Lin D. Exome-wide analyses identify low-frequency variant in CYP26B1 and additional coding variants associated with esophageal squamous cell carcinoma. Nat Genet. 2018; 50(3):338-343.

4. Gong J, Tian J, Lou J, Wang X, Ke J, Li J, Yang Y, Gong Y, Zhu Y, Zou D, Peng X, Yang N, Mei S, Zhong R, Chang J, Miao X. A polymorphic MYC response element in KBTBD11 influences colorectal cancer risk, especially in interaction with an MYC-regulated SNP rs6983267. Ann Oncol. 2018;29(3):632-639.

5. Chang J, Tian J, Zhu Y, Zhong R, Zhai K, Li J, Ke J, Han Q, Lou J, Chen W, Zhu B, Shen N, Zhang Y, Gong Y, Yang Y, Zou D, Peng X, Zhang Z, Zhang X, Huang K, Yang M, Wang L, Wu C*, Lin D*, Miao X*.Exome-wide analysis identifies three low-frequency missense variants associated with pancreatic cancer risk in Chinese populations. Nat Commun. 2018;9(1):3688.

6. Chang J, Tian J, Yang Y, Zhong R, Li J, Zhai K, Ke J, Lou J, Chen W, Zhu B, Shen N, Zhang Y, Gong Y, Zhu Y, Zou D, Peng X, Huang K, Miao X. A rare missense variant in TCF7L2 associates with colorectal cancer risk by interacting with a GWAS-identified regulatory variant in the MYC enhancer. Cancer Res. 2018;78(17):5164-5172.

7. Li J, Chang J, Tian J, Ke J, Zhu Y, Yang Y, Gong Y, Zou D, Peng X, Yang N, Mei S, Wang X, Cheng L, Hu W, Gong J, Zhong R, Miao X. A rare variant P507L in TPP1 interrupts TPP1-TIN2 interaction, influences telomere length, and confers colorectal cancer risk in Chinese population. Cancer Epidemiol Biomarkers Prev. 2018;27(9):1029-1035.

8. Zou D, Lou J, Ke J, Mei S, Li J, Gong Y, Yang Y, Zhu Y, Tian J, Chang J, Zhong R, Gong J, Miao X. Integrative expression quantitative trait locus-based analysis of colorectal cancer identified a functional polymorphism regulating SLC22A5 expression. Eur J Cancer. 2018;93:1-9.

9. Lou J, Gong J, Ke J, Tian J, Zhang Y, Li J, Yang Y, Zhu Y, Gong Y, Li L, Chang J, Zhong R, Miao X. A functional polymorphism located at transcription factor binding sites, rs6695837 near LAMC1 gene, confers risk of colorectal cancer in Chinese populations. Carcinogenesis. 2017;38(2):177-183.

10. Gong J, Tian J, Lou J, Ke J, Li L, Li J, Yang Y, Gong Y, Zhu Y, Zhang Y, Zhong R, Chang J, Miao X. A functional polymorphism in lnc-LAMC2-1:1 confers risk of colorectal cancer by affecting miRNA binding. Carcinogenesis. 2016;37(5):443-451.


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