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师资概况
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来源: 时间:2022-06-10 点击量:




职务:教授,博士生导师

院系:卫生毒理学系

地址:湖北省武汉市航空路13号 430030

邮箱:yanhong@mails.tjmu.edu.cn


1992年本科毕业于同济医科大学环境医学专业,1995和1998年同济医科大学卫生毒理学系研究生,获医学硕士和博士学位,2007.11-2008.12获国家留学基金委资助作为访问学者在美国University of Pennsylvania学习。自1998年7月毕业留校任教以来,一直从事卫生毒理学教学与科研工作,负责毒理学基础和毒理学进展的课程教学,指导的本科毕业论文获湖北省优秀学士学位论文奖。研究方向为外源化学物毒性作用及分子机制,主要关注环境化学物与神经退行性疾病的关系。主持多项国家自然科学基金面上项目、教育部留学回国启动基金和中央高校自主创新研究基金等科研项目,并参加国家自然科学基金重点项目。主要社会兼职有湖北省毒理学会常务理事、中华预防医学会卫生毒理学分会委员、中国毒理学会生化与分子毒理学专委会、神经毒理学专委会和毒理学教育专委会委员。参加编写《食品毒理学》(副主编)、《毒理学基础》双语教材等。



近年发表主要论文(通讯作者)


1. Yan Dandan, Dai Lingling,Zhang Xing,Wang, Yiqi,Yan, Hong*,Subchronic Acrylamide Exposure Activates PERK-eIF2alpha Signaling Pathway and Induces Synaptic Impairment in Rat Hippocampus.ACS chemical neuroscience, 2022,13(9):1370-1381

2. Dandan Yan, Na Wang, JianlingYao, XuWu, JingpingYuan , Yan, Hong*,Curcumin Attenuates the PERK-eIF2α Signaling to Relieve Acrylamide-Induced Neurotoxicity in SH‑SY5Y Neuroblastoma Cells Neurochemical Research, 2022, 47:1037–1048

3. Yiqi Wang, Lian Duan, Xing Zhang,Yang Jiao, Ying Liu, Lingling Dai ,Hong Yan* ,Effect of long-term exposure to acrylamide on endoplasmic reticulum stress and autophagy in rat cerebellum, Ecotoxicology and Environmental Safety 2021,224:112691

4. Ying Liu# , Dandan Yan# ,Yiqi Wang,Xing Zhang, Na Wang,  Yang Jiao ,Hong Yan*.Subchronic exposure to acrylamide caused behaviour disorders and related pathological and molecular changes in rat cerebellum.Toxicology Letters, 2021,340 : 23–32

5. Yiqi Wang, Ying Liu, Hong Yan*,Effect of Long-term Particulate Matter Exposure on Parkinson’s Risk", Environmental Geochemistry and Health.2020 ,42:2265–2275

6. Ying Liu , Xing Zhang,, Dandan Yan , Yiqi Wang , Na Wanga , Yufan Liu , Aijun Tan,Xiaoyi Chen , Hong Yan*.Chronic acrylamide exposure induced glia cell activation, NLRP3 inflammasome upregulation and cognitive impairment. Toxicology and Applied Pharmacology,2020, 393: 114949

7. Dandan Yan, Xiaoqi Pan,Jianling Yao, Dun Wang, Xu Wu, Xiaoyi Chen, Nian Shi, Hong Yan*. MAPKs and NF-κB mediated acrylamide-induced neuropathy in rat striatum and human neuroblastoma cells SY5. Journal of Cellular Biochemistry. 2019.3, 120: 3898~3910

8. Dandan Yan, Jianling Yao,Ying Liu, Xing Zhang, Yiqi Wang, Xiaoyi Chen, Liegang Liu, Nian Shi, Hong Yan*. Tau hyperphosphorylation and P-CREB reduction are involved in acrylamide-induced spatial memory impairment: Suppression by curcumin.  Brain, Behavior, and Immunity. 2018, 71: 66-80

9. Xiaoqi Pan, Xu Wu, Dandan Yan, Cheng Peng, Chaolong Rao, Hong Yan*. Acrylamide-induced oxidative stress and inflammatory response are alleviated by N-acetylcysteine in PC12 cells: Involvement of the crosstalk between Nrf2 and NF-κB pathways regulated by MAPKs.  Toxicology Letters.2018,288:55-64

10. Dandan Yan, Yunjian Zhang, Liegang Liu, Nian Shi, Hong Yan*. Pesticide exposure and risk of Parkinson's disease: Dose-response meta-analysis of observational studies. Regulatory Toxicology and Pharmacology. 2018, 96:57-63

11. Xiaoqi Pan, Dandan Yan, Dun Wang, Xu Wu, Wanyun Zhao, Qing Lu, Hong Yan*. Mitochondrion-mediated apoptosis induced by Acrylamide is regulated by a balance between Nrf2 antioxidant and MAPK signaling pathways in PC12 Cells. Molecular Neurobiology. 2017; 54(6):4781-4794






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